# A novel platform for the discovery and characterization of migraine therapies

> **NIH NIH R61** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $455,371

## Abstract

PROJECT SUMMARY
A major obstacle for the identification and characterization of new therapies for migraine and pain has been
limitations of the animal models used to study these therapies. We have developed a novel approach that
addresses this obstacle: a minimally invasive skull-attached microchip-based system and video
recording/analysis system that enables continuous recording and triggering of neurovascular activity and
behavior over months. We will further develop and validate this approach as a novel platform for the discovery
and characterization of migraine therapies. We will:
1. Quantify a comprehensive set of neurovascular and behavioral responses to established human
migraine triggers and cortical spreading depression (CSD) using the microchip/video platform.
2. Use the microchip/video platform to characterize the effects of acute migraine therapies on the
response to established migraine triggers and CSD to validate the platform as a useful tool for the
discovery and characterization of acute therapies
3. Use the microchip /video platform to characterize the effects of migraine preventive therapies.
Key findings will be independently replicated at two different institutions.
The platform described in this proposal represents a significant advance in our efforts to find new approaches
to the treatment of migraine, a highly prevalent and disabling nervous system disorder.

## Key facts

- **NIH application ID:** 10973532
- **Project number:** 1R61NS133274-01A1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** ANDREW C CHARLES
- **Activity code:** R61 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $455,371
- **Award type:** 1
- **Project period:** 2024-09-01 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10973532

## Citation

> US National Institutes of Health, RePORTER application 10973532, A novel platform for the discovery and characterization of migraine therapies (1R61NS133274-01A1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10973532. Licensed CC0.

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