# TLT-1 intracellular function

> **NIH NIH R15** · OAKLAND UNIVERSITY · 2024 · $434,658

## Abstract

Project Summary/Abstract
TREM Like transcript (TLT-1), is a highly abundant platelet protein that mediates the earliest
states of platelet activation. Inhibition of TLT-1 function is associated with bleeding in the
inflammatory arena; however vascular hemostasis does not seem to be adversely affected. Our
studies have shown that TLT-1 presents itself as a potential target to control thrombosis without
the introduction of bleeding. However, to pursue the therapeutic aspects of TLT-1, we must first
understand the mechanisms of TLT-1 function. This project is focused on identifying the critical
signaling motifs of TLT-1 function. To accomplish this goal, we have outlined two specific AIMs:
Aim 1: Characterize TLT-1 phosphorylation sites, Aim 2: Decipher the intracellular cues
that regulate TLT-1 trafficking in platelets At the completion of these aims we will have a
clear understanding of the importance of the platelet to regulation of edema and how we can
manipulate platelet interactions to improve disease outcomes.

## Key facts

- **NIH application ID:** 10974515
- **Project number:** 1R15HL175494-01
- **Recipient organization:** OAKLAND UNIVERSITY
- **Principal Investigator:** A. Valance Washington
- **Activity code:** R15 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $434,658
- **Award type:** 1
- **Project period:** 2024-09-01 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10974515

## Citation

> US National Institutes of Health, RePORTER application 10974515, TLT-1 intracellular function (1R15HL175494-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10974515. Licensed CC0.

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