# Understanding Neurocognition in Youth with Type 1 Diabetes (UNYT1D) Biostatistics Research Center (BRC)

> **NIH NIH U01** · UNIVERSITY OF MINNESOTA · 2024 · $1,858,285

## Abstract

Summary
 Type I diabetes (T1D) is one of the most common chronic diseases in childhood. Sequelae of pediatric T1D
include neurocognitive dysfunction in attention, psychomotor speed, mental efficiency, visual-motor skills,
memory, and learning possibly due to damage to posterior white matter tracts and associated gray matter
regions. Emerging evidence suggests that diabetic ketoacidosis at time of diagnosis, glucose control, diabetes
device use, sleep, and caregiver distress may be important factors that influence neurocognitive development.
However, there is minimal data in this area and existing studies are limited by small sample size, short
follow-up time, and a lack of diversity in patient populations. A contemporary, adequately powered longitudinal
study in a diverse cohort of prepubescent children is needed to understand the mechanisms associated with
neurocognitive perturbations, critical periods for prevention and intervention, and strategies to mitigate the risk
of neurocognitive complications in later life.
 Our research team is uniquely qualified to serve as the Biostatistics Research Center (BRC) for the
Understanding Neurocognition in Youth with Type 1 Diabetes (UNYT1D) nation-wide consortium combining
extensive experience in the coordination of multi-site clinical studies and research networks, biostatistics
expertise in the analysis of complex observational data, and expertise in T1D, glucose variability,
neurocognition, and neuroimaging. Our application leverages the existing infrastructure of the University of
Minnesota’s Coordinating Centers for Biometric Research (CCBR), which has internationally recognized
expertise in coordinating complex, large-scale, multi-site studies and networks and over 50 years of experience
These substantial strengths enable the BRC to accomplish the following specific aims:1) Partner with NIDDK to
provide scientific leadership in the design of a longitudinal cohort study to characterize the neurocognitive
impact of new onset T1D in pre-pubertal children; 2) Provide overall coordination of the national multisite
consortium in the planning and implementation of and adherence to the protocol; 3) Provide consortium-wide
resources for data harmonization, pipelines, management and sharing; 4) Provide expertise in all aspects of
study reporting, data analysis and dissemination.
 The BRC will play a crucial role in the success of the consortium. Our research team has a proven
track-record of high-impact research in the clinical management of T1D, a history of developing novel
approaches to neuroimaging data acquisition and analysis, and extensive experience coordinating the
activities of and providing statistical and data management support for multi-site clinical studies and research
networks. Leveraging this experience and capitalizing on the existing infrastructure of the CCBR, we are
uniquely suited to serve as the BRC and support high-quality, robust, and reproducible research through the
UNYT1D consort...

## Key facts

- **NIH application ID:** 10975099
- **Project number:** 1U01DK140777-01
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** Lynn E Eberly
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,858,285
- **Award type:** 1
- **Project period:** 2024-08-15 → 2029-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10975099

## Citation

> US National Institutes of Health, RePORTER application 10975099, Understanding Neurocognition in Youth with Type 1 Diabetes (UNYT1D) Biostatistics Research Center (BRC) (1U01DK140777-01). Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/grant/nih/10975099. Licensed CC0.

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