ABSTRACT Indigenous peoples in the United States and worldwide face the starkest inequities in premature mortality of any racial and ethnic group. In the United States, American Indian/ Alaska Native (AI/AN) Peoples have 2X higher rates of suicide, 4X higher rates of alcohol induced deaths, and 1.6X higher drug overdose deaths compared to the US general population. To effectively drive change in the staggering inequities, we need a scientific workforce that better represents Indigenous peoples. To date, Indigenous and other diverse scholars are vastly underrepresented in NIH funding, including fellowship and training grants. The parallel inequities in public health education, training, and preventable cause mortality stem from historical and contemporary social and structural determinants. The goal of the Elevating Indigenous Wellbeing through Assets-Based Prevention Science (ELEVATE) Training Program is to train Indigenous and other diverse predoctoral scholars to become leaders in health equity research and strengths-based multi-level prevention science, addressing worsening inequities in mental- and behavioral-health-related premature mortality among Indigenous Peoples. To accomplish this goal, we will provide rigorous training and high-quality mentorship in (1) Health disparities/health equity research, (2) Developing and implementing multi-level prevention interventions, and (3) Methods to design and analyze studies that evaluate multi-level prevention interventions. We will also provide cross-cutting training in (4) Indigenous methodologies as a way to root this training and decolonizing approaches. Trainees well benefit from the program’s interdisciplinary and team-based mentorship and training approach. The ELEVATE program will he led by a team of Indigenous and allied leaders and leverage the vast resources of the Johns Hopkins Blumberg School of Public Health, including the Center for Indigenous Health’s (CIH) 40+ year trust-relationships with Tribal Nations and growing number of Indigenous and allied faculty. Specifically, the ELEVATE program will be housed in the Social and Behavioral Interventions program, but the 3 trainees per year may also come from the Department of Mental Health or full-time students from the school wide Doctorate of Public Health Program. Trainees well undertake a rigorous program of coursework in health equity, multilevel prevention, and associated and Indigenous methodologies. A year-long seminar to discuss research in progress, ongoing mentored research projects, and integrative activities will complement coursework. ELEVATE will synergize with CIH’s NIDA-funded P50 National Center for Excellence, Community-Driven Indigenous Research, Cultural Strengths & Leadership to Advance Equity in Drug Use Outcomes (CIRCLE). This proposed program aligns directly with the goal of the ADVANCE Predoctoral T32, the cross-cutting themes for the Office of Disease Prevention’s strategic plan, and would address key cross-cutti...