# Gateway Exposome Coordinating Center (GECC) For AD/ADRD Research

> **NIH NIH U24** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $4,943,526

## Abstract

Project Summary
We propose a coordinating center that brings together experts and stakeholders to identify exposome research
priorities, develop harmonized exposome measures based on those priorities, and establish guidance and best
practices for use of exposome data to advance the science of AD/ADRD risk, resilience, and disparities.
Leveraging and building upon the expertise gained from the successful development and expansion of the
Gateway to Global Aging Data (the Gateway) platform, we propose to establish a research coordinating center,
the Gateway Exposome Coordinating Center (GECC) for AD/ADRD Research. Given the wide diversity in
exposures that occur over the life course, there is a critical need to facilitate discussions, engagements, and
collaborations between researchers and stakeholders across many disciplines to create a central source of
measures, guidance, and tools for the scientific community working on AD/ADRD outcomes.
 We propose the GECC to build consensus inclusively and transparently among experts and key
stakeholders around six key, interconnected domains: Climate, Physical Environment, Social Environment,
Policies, Community Services, and Life Experiences. The GECC will serve as a centralized hub for identifying
and setting priorities, reaching consensus, and establishing guidance on accessing, developing, harmonizing,
and sharing innovative exposome measures and data for the broader AD/ADRD research and stakeholder
community. We will do this by (1) identifying key experts and stakeholders across disciplines within each
domain, (2) organizing those experts and stakeholders through activities aimed at identifying key exposome
measures and creating consensus around their prioritization and definition and, when lacking consensus,
supporting research to facilitate consensus, (3) promoting within and cross-domain engagements to inspire
innovation, understanding, the creation of common measurements, and collaborations, and (4) disseminating
data, findings, and guidance from the GECC’s activities so that they can be used by the broader community
and establish a published record of our decision-making and inform future generations of researchers.
 In addition to leading the development of exposure measures, the GECC will also promote and support
others in developing and harmonizing exposome data, including NIA-supported infrastructure projects, center
and network programs and other interested researchers and projects. This support will come through
publishing detailed guidance documents, organizing capacity-building workshops, and the GECC’s pilot
program. The GECC will further encourage innovations and participation from the broader scientific community
through publications, research briefs, webinars, hackathons, exhibits, and social media, as well as the Center’s
in-person and virtual workshops. Collectively, the activities of the GECC to establish consensus around core
and innovative exposome measures and promote their harmon...

## Key facts

- **NIH application ID:** 10975562
- **Project number:** 1U24AG088894-01
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** Sara Adar
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $4,943,526
- **Award type:** 1
- **Project period:** 2024-08-01 → 2029-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10975562

## Citation

> US National Institutes of Health, RePORTER application 10975562, Gateway Exposome Coordinating Center (GECC) For AD/ADRD Research (1U24AG088894-01). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10975562. Licensed CC0.

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