The overarching objective of this proposal is to increase the quantitative and data management capabilities of graduate students, postdoctoral fellows, and early- to mid-career faculty by providing training in quantitative research methods and hands-on analysis and programming experience with the All of Us Researcher Workbench. Our team has extensive experience engaging and training researchers to work with the All of Us Research Program. Building on this foundation, we will utilize the Social-Ecological Researcher Engagement Framework to expand our proven engagement strategies while implementing novel approaches to train graduate students, postdoctoral fellows, and early- to mid-career faculty on advanced quantitative and programming skills using the All of Us Research Program. This proposal incorporates four evidence-based approaches for increasing access to high-quality, large-scale data and promoting quantitative and data management capabilities through research training and hands-on experience with the All of Us Researcher Workbench. These approaches include collaboration with institutions across the United States to integrate knowledge, resources, and training as well as increase awareness of the All of Us Researcher Workbench; training in highly relevant and deployable quantitative and data science skills for graduate students and postdoctoral fellows; strengthening the quantitative expertise of postdoctoral fellows and early- to mid-career faculty; and provision of ongoing technical assistance, including statistical guidance, webinars, and individual project support to collaborative institutions to facilitate accessibility and usability of the All of Us Researcher Workbench. This program is critical to the development of a quantitatively skilled public health workforce at multiple levels, from graduate training through mid-career faculty. These engagement activities have the potential to foster long-term change in the landscape of public health scholarship by cultivating a more diverse and equitable workforce that spearheads important innovations in the field.