# Chromosome Packing Inhibitors for the Treatment of Eye Infections

> **NIH NIH R21** · UNIVERSITY OF OKLAHOMA · 2024 · $201,825

## Abstract

Chromosome Packing Inhibitors for the Treatment of Eye Infections
ABSTRACT
Bacterial eye infections frequently arise as a complication of corrective surgery or contact lens use.
Therapeutic treatment of such infections is often complicated by intrinsic and acquired drug resistant
mechanisms, which eventually leads to irreversible eye damage and vision loss. Identification of antibacterial
compounds with a new mode of action could potentially alleviate this problem. This project seeks to evaluate
condensin inhibitors for efficacy during ocular infections. Condensins play a central role in global chromosome
organization and segregation and are required for virulence in diverse bacteria. In Pseudomonas aeruginosa,
condensins are integrated into the control of lifestyle and virulence and are required during eye infection. This
project will investigate how the inhibition of condensins affects the interaction of P. aeruginosa with the host
and examine the efficacy of the lead condensin inhibitor in an in vivo model of bacterial keratitis.

## Key facts

- **NIH application ID:** 10975696
- **Project number:** 1R21EY036599-01
- **Recipient organization:** UNIVERSITY OF OKLAHOMA
- **Principal Investigator:** VALENTIN V RYBENKOV
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $201,825
- **Award type:** 1
- **Project period:** 2024-09-01 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10975696

## Citation

> US National Institutes of Health, RePORTER application 10975696, Chromosome Packing Inhibitors for the Treatment of Eye Infections (1R21EY036599-01). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10975696. Licensed CC0.

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