# Patient-Centered Outcomes in Carotid Artery Stenosis

> **NIH NIH R03** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $308,000

## Abstract

Project Summary Abstract
Older patients with carotid artery atherosclerotic disease are at risk of stroke, and some evidence suggests
that people are affected by their carotid artery stenosis even in the absence of a stroke. These non-stroke
outcomes are poorly studied, but may include cognitive decline, sleep disturbances, and mood abnormalities.
Whether medication or surgery for carotid artery stenosis improves these non-stroke symptoms is unclear.
Therefore, it is necessary to identify the best way to measure these non-stroke patient-reported outcomes to
be able to study how carotid artery stenosis treatment affects these symptoms. A reliable and accurate
measurement of patient-reported outcomes in carotid artery stenosis will enable identification and tracking of
these symptoms throughout the treatment continuum.
Research Aim 1 of this project will use instruments developed by the National Institutes of Health to measure
quality-of-life and function across diseases, as well as a robust, multidimensional assessment of cognition (NIH
Patient-Reported Outcomes Measurement Information System; NIH Toolbox-Cognitive Battery). These will be
collected on people with a diagnosis of carotid artery stenosis, including those with prior medical or surgical
treatment, and newly diagnosed carotid artery disease requiring surgery. Patients will have at least two
timepoints 6 months apart, with more frequent assessments directly after surgery in patients undergoing
surgery during this study period.
Research Aim 2 of this project will use interviews and focus groups to gain patient and caregiver perspectives
about non-stroke changes that may have occurred after revascularization for carotid artery stenosis. This data
will help select the best measures of non-stroke outcomes for carotid artery stenosis to be used in large scale
trials evaluating which treatment is best for which patients.
For older patients with carotid artery disease, this research will ensure better alignment of treatment with the
4M Geriatric Framework of Age-Friendly Health Systems. With this lens, we will better understand how to align
treatment of carotid artery stenosis with 1) what matters most to patients, 2) how medication treatment effects
older patients, 3) how treatment can improve mentation, and 4) how to promote mobility and independence in
this complex patient population.

## Key facts

- **NIH application ID:** 10976300
- **Project number:** 1R03AG088969-01
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** Cali Johnson
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $308,000
- **Award type:** 1
- **Project period:** 2024-09-01 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10976300

## Citation

> US National Institutes of Health, RePORTER application 10976300, Patient-Centered Outcomes in Carotid Artery Stenosis (1R03AG088969-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10976300. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*