# Neurostimulation Enhanced Cognitive Restructuring for Transdiagnostic Emotional Dysregulation: A Component Analysis

> **NIH NIH R01** · DUKE UNIVERSITY · 2024 · $13,718

## Abstract

This application proposes the addition of data collection and hypotheses for the parent R01 in support of the
training of a very promising graduate student from an under-represented background. Using data from a
completed pilot study in individuals with emotion dysregulation, our team has shown that task-based functional
activity and connectivity in the insula are associated with induction of negative emotion, utilization of emotion
regulation skills, and emotion dysregulation severity. In a comparison group of non-clinical participants,
utilization of emotion regulation skills was associated with increased functional connectivity strength between
the insula and the mPFC, a default mode network node. These findings suggest that dynamics between the
salience and other large-scale prefrontal networks differ between emotionally dysregulated and non-clinical
participants. Therefore, the supplement plans to examine the hypothesis that cortico-insular connections are
critically involved in emotion dysregulation and may be a mechanism for the therapeutic response to
neuromodulatory perturbation. Ms. Gerlus is planning to learn and employ a connectomic approach to
determine how cortico-insular connectivity is related to emotion dysregulation and affected by brain stimulation.
The skills and training proposed would allow her to establish the foundation for a physician-scientist career at
the intersection of psychiatry and neuroscience and would serve as the basis for her dissertation.

## Key facts

- **NIH application ID:** 10977154
- **Project number:** 3R01MH129302-02S1
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Andrada Delia Neacsiu
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $13,718
- **Award type:** 3
- **Project period:** 2024-03-01 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10977154

## Citation

> US National Institutes of Health, RePORTER application 10977154, Neurostimulation Enhanced Cognitive Restructuring for Transdiagnostic Emotional Dysregulation: A Component Analysis (3R01MH129302-02S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10977154. Licensed CC0.

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