# Alcohol misuse and oxidative stress among diverse sexual minority young adults

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $54,580

## Abstract

DIVERSITY SUPPLEMENT PROJECT SUMMARY
The overarching goal of this diversity supplement is to evaluate links among alcohol use, alcohol misuse, and
oxidative stress among a diverse sample of sexual minority young adults. I propose to analyze secondary data
from the Population Assessment of Tobacco and Health (PATH) study to address the proposed aims that fall
within the scope of the parent grant’s research objectives and expand upon it by identifying prospective
patterns of oxidative stress related to alcohol use (frequency) and alcohol misuse (quantity, e.g., binge
drinking) as indicators of health. Guiding the proposal are three specific aims: (1) Characterize longitudinal
changes of oxidative stress via 8-Isoprostane over 3 years by sociodemographic characteristics (sexual
orientation/identity, sex, race, ethnicity, socioeconomic status) among sexual minority young adults. (2)
Describe longitudinal associations between alcohol use, alcohol misuse, and 8-Isoprostane over 3-years
among sexual minority young adults. (3) Determine whether associations between alcohol use, alcohol misuse,
and 8-Isoprostane over 3 years differ by sociodemographic characteristics (sexual orientation/identity, sex,
race, ethnicity, socioeconomic status). To test these aims, I propose sophisticated quantitative methodology
including parallel latent growth curve analyses which are rarely used to examine longitudinal associations
between alcohol use and misuse and oxidative stress among sexual minority young adults. The proposed
research will help to determine whether specific subgroups of sexual minority young adults are at greatest risk
for immediate care and support. With the mentorship of Dr. Rebecca Evans-Polce and Dr. Sean Esteban
McCabe, this diversity supplement training will allow me to: (1) expand my knowledge in the impacts of alcohol
use and alcohol misuse on biological processes among diverse sexual minorities across young adulthood, (2)
become proficient in analyzing large nationally representative longitudinal data, (3) and improve my grant
writing skills. The training acquired through this diversity supplement will position me to obtain my long-term
career objective of becoming a leader in NIH-funded research on the associations among minority stressors,
alcohol misuse, and other behavioral problems, and biological stress processes as determinants of health
among diverse sexual minority populations.

## Key facts

- **NIH application ID:** 10978010
- **Project number:** 3R01AA030243-02S1
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Rebecca J Evans-Polce
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $54,580
- **Award type:** 3
- **Project period:** 2024-03-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10978010

## Citation

> US National Institutes of Health, RePORTER application 10978010, Alcohol misuse and oxidative stress among diverse sexual minority young adults (3R01AA030243-02S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10978010. Licensed CC0.

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