Project Summary/Abstract The primary goal of this P20 planning grant is to establish the Mni Sota Center for Climate Change and Health by developing a network of scientists and community members to build capacity for climate and health research. The evolving nature of how a changing climate is impacting health will require collaborations involving scientists, public health professionals, and community partners to identify critical health concerns and create solutions for adaptation. To address this need he MC3H will administer a Pilot Project and Emerging Issues Program. The overall goal of this program is to develop new initiatives and partnerships in climate and health research that will create a substantial and sustainable research agenda for climate change and health with specific goals as follow. 1) Lay the foundation for innovative and impactful programs that address emerging and persistent challenges related to the health impacts of climate change. 2) Facilitate the development of multidisciplinary and cross-sectoral partnerships to build capacity for research related to climate change and health utilizing existing and novel data and community resources. 3) Engage regional community partners to be involved with climate change and health research with an emphasis on rural and American Indian communities. 4) Respond to rapidly evolving emerging and re-emerging issues related to the health impacts of climate change. 5) Develop cutting edge research pilot projects on the health impacts of climate change that have high probability of obtaining additional and substantial funding. Areas of emphasis will be annually derived from a research agenda co-developed by the Community Engagement Core and community partners with input from the External Advisory Board. A funding opportunity announcement will be developed and delivered annually to potential investigators in academia, government, non-governmental organizations, and Tribal communities. The center will facilitate partnerships between experienced and less experienced investigators to propose and conduct pilot research and develop subsequent high-quality proposals for more substantial projects in a timely manner. The proposals will be reviewed for scientific and programmatic merit and final funding decisions will be made by the Center Director. The center will establish protocols and that promote best practices when conducting research with American Indian communities and for sharing results with communities. Communication back to the relevant communities will be required. The center will track and evaluate the progress of the research and work with the grant recipients on the process of preparing follow-up proposals to ensure conversion of the pilot research into more substantive projects. Additionally, with input from the External Advisory Board and community partners time critical emerging issues will be identified that can be investigated by center staff to yield novel information related to c...