# Cbfb in RORgt-regulated T cell function

> **NIH NIH R01** · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2024 · $753,164

## Abstract

Retinoid-related orphan receptor gamma t (RORyt) is a transcription factor that regulates the
differentiation of Th17 cells in the peripheral immune system and the development of
thymocytes in the central immune system. As pathogenic Th17 cells are responsible for tissue
damages associated with many types of autoimmune diseases including multiple sclerosis,
psoriasis and inflammatory bowel disease, there is a medical need for the development of
RORyt-based therapies to treat these autoimmune diseases. However, inhibition of RORyt, that
ameliorates Th17-mediated autoimmune diseases, also disrupts thymocyte development and
thus prevents the replenishment of the peripheral immune system with T cells critical for
clearance of infection by pathogens such as bacteria and virus. Further, inhibition of RORyt
activity could lead to the development of cancer. We thus propose to separate RORyt function in
Th17 cells and thymocytes by characterizing its shared and unique co-factors in these two types
of cells, which will facilitate to achieve the long-term goal of development of RORyt-based
therapies for treatment of autoimmune disease with minimum toxic side effects.

## Key facts

- **NIH application ID:** 10981789
- **Project number:** 2R01AI109644-11A1
- **Recipient organization:** BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
- **Principal Investigator:** Zuoming Sun
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $753,164
- **Award type:** 2
- **Project period:** 2014-05-01 → 2029-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10981789

## Citation

> US National Institutes of Health, RePORTER application 10981789, Cbfb in RORgt-regulated T cell function (2R01AI109644-11A1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10981789. Licensed CC0.

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