# CLINTRUSC Research Design Core (RDCD)

> **NIH NIH P20** · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2024 · $430,537

## Abstract

Abstract A critical component in in successfully conducting clinical and translational (C&T) research is to
achieve the optimal standards of rigor and reproducibility of research methods, and the Research Design,
Compliance and Data Management (RDCD) Core is strategically designed to achieve this goal by providing
the infrastructure and expertise necessary for high-quality, innovative C&T research within the CLINTRUSC
research network. With expertise in biostatistics, research study design, and electronic heath record (her), the
RDCD core will provide C&T researchers across CLINTRUSC with training, consultation, and collaboration.
Specifically, we will enhance research compliance by training and mentoring CLINTRUSC
investigators/professional staff in conducting C&T human subjects research including observational and
prospective studies (Aim 1); provide C&R researchers in the CLINTRUSC network with biostatistics and
research design support including assistance with designing clinical and community-based study protocols,
and performing sample size calculations, power calculations, and biostatistical analyses to ensure rigor and
avoid methodological bias (Aim 2); and establish and enhance procedures to facilitate the use of EHR for
research, including data acquisition, curation, management, and analysis (Aim 3). In addition, the RDCD Core
will work in close collaboration with other CLINTRUSC Cores, including the Administrative Core (Aims 1-3),
Professional Development Core (Aim 1), and the Health Research (Aims 2-3) Cores. The RDCD core will
interact across CLINTRUSC network to ensure that RDCD expertise is effectively distributed across the entire
CLINTRUSC in a manner proportional to the need for RDCD expertise. Metrics to measure impact of the
RDCD Core include the number of 1) research consultations; 2) collaborative grant proposals submitted and
funded; 3) collaborative manuscripts; 4) citations to this work; 5) workshops and seminars organized; 6)
individuals put on local protocols; and 7) junior faculty researchers mentored.
The RDCD Core’s underlying premise is that embedding RDCD expertise in CLINTRUSC in a transdisciplinary
team science environment will elevate the quality of the research and facilitate a more rapid translation into
improved health. To achieve this, the RDCD Core will promote leading-edge, innovative clinical, and
translational research to ensure that scientific questions are addressed using optimally efficient, unbiased
study designs and applying appropriate analytic approaches, cultivate expertise in C&T in biostatistics, data
science, data security, data cybersecurity and artificial intelligence to support RDCD Core needs, and enhance
research infrastructure. The endeavors will support the overall goal of CLINTRUSC: to positively impact
population health by carrying out impactful translational research with the promise of improving evidence-
based clinical medicine and public health practice.

## Key facts

- **NIH application ID:** 10984241
- **Project number:** 1P20GM155896-01
- **Recipient organization:** UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
- **Principal Investigator:** Jiajia Zhang
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $430,537
- **Award type:** 1
- **Project period:** 2024-07-15 → 2029-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10984241

## Citation

> US National Institutes of Health, RePORTER application 10984241, CLINTRUSC Research Design Core (RDCD) (1P20GM155896-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10984241. Licensed CC0.

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