# GMP Production and Extended Toxicology of an Oral Formulation Drug for Alzheimer's Disease

> **NIH NIH U01** · NORTHWESTERN UNIVERSITY · 2024 · $1,370,663

## Abstract

ABSTRACT
This is an administrative supplement application to U01 AG076480, to request costs due to unforeseen
circumstances. These additional proposed activities are within the scope of the U01 project but were
unexpected at the time of award. For example, the length and breadth of the COVID-19 pandemic were not
anticipated by public health or other government agencies. The pandemic caused several downstream hurdles,
including scheduling delays with CROs, supply chain shortages, and dramatic cost increases. The effect was
profound for the GMP drug manufacturing and testing (aim 1) and the extended GLP toxicology studies (aim
2). Therefore, we are requesting an administrative supplement to allow us to complete the specific aims and
meet the milestones of our AG076480.

## Key facts

- **NIH application ID:** 10984354
- **Project number:** 3U01AG076480-03S1
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** LINDA J VAN ELDIK
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,370,663
- **Award type:** 3
- **Project period:** 2022-06-01 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10984354

## Citation

> US National Institutes of Health, RePORTER application 10984354, GMP Production and Extended Toxicology of an Oral Formulation Drug for Alzheimer's Disease (3U01AG076480-03S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10984354. Licensed CC0.

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