# Next-generation Lasers for Enabling Ultrafast Functional Pulmonary MRI > **NIH NIH R21** · WAYNE STATE UNIVERSITY · 2024 · $231,207 ## Abstract PROJECT SUMMARY (30-line limit) Deadly lung diseases such as chronic obstructive pulmonary disease, asthma, lung injury, constrictive bronchiolitis, and pulmonary fibrosis affect >300 million people worldwide and cause ~3 million annual deaths. Moreover, the COVID-19 pandemic and the lingering effects of Long COVID have exacerbated lung disease morbidity and mortality. Indeed, despite the vast morbidity and mortality of lung diseases, there is currently no widespread clinical imaging modality to perform high-resolution functional lung imaging: CT, conventional MRI, and chest X-ray generally only provide structural images of dense tissues—informing about pathologies like tumors and pneumonia—but yielding little information about lung ventilation, perfusion, alveoli size, gas- exchange efficiency, etc. This state of affairs contrasts with cancer imaging, which includes MRI, CT, ultrasound, mammography, Positron Emission Tomography, which collectively enable early detection, diagnoses, and monitoring response to treatment. Pulmonary functional MRI using hyperpolarized Xenon-129 gas was FDA approved in December 2022 because it enables 3D imaging of lung function on a single breath hold and reports on regional lung ventilation, diffusion, and gas exchange. Despite effectiveness and safety of hyperpolarized Xenon-129 gas MRI to diagnose a wide range of lung diseases, widespread clinical adaptation of this imaging modality faces major translational challenges, including the high cost and complexity of the equipment for production of hyperpolarized Xenon-129 gas. The central and most expensive component (and frequent point of failure) of a xenon-129 hyperpolarizer device is the high-power laser diode array (LDA) that provides the resonant light used to polarize the xenon-129 spins. Current xenon-129 hyperpolarizers employ lasers with ~0.3-nm bandwidths; although a significant improvement from the multi-nanometer linewidths of previous un-narrowed LDAs, it is still several-fold wider than the intrinsic linewidths of atomic absorption lines. This mismatch often results in most of the laser light being wasted. Next-generation lasers have recently become available that can provide unprecedented control of the LDA bandwidth down to ~0.02 nm – an order-of-magnitude improvement over current-generation systems. This advance allows the laser output to be matched to the narrow atomic absorption lines, potentially enabling the Xenon-129 hyperpolarization efficiency to be improved by several fold! If successful, this innovation should lead to the development of substantially more efficient and easier-to-site hyperpolarization instrumentation for clinical-scale production of hyperpolarized Xenon-129 contrast agent. Here, we propose to explore and characterize the Xenon-129 hyperpolarization performance of this next- generation laser technology. We will investigate the utility of tunable laser bandwidth – in addition to tunable wavelength and laser power – for increas... ## Key facts - **NIH application ID:** 10984522 - **Project number:** 1R21HL168430-01A1 - **Recipient organization:** WAYNE STATE UNIVERSITY - **Principal Investigator:** Eduard Chekmenev - **Activity code:** R21 (R01, R21, SBIR, etc.) - **Funding institute:** NIH - **Fiscal year:** 2024 - **Award amount:** $231,207 - **Award type:** 1 - **Project period:** 2024-09-01 → 2026-06-30 ## Primary source NIH RePORTER: https://reporter.nih.gov/project-details/10984522 ## Citation > US National Institutes of Health, RePORTER application 10984522, Next-generation Lasers for Enabling Ultrafast Functional Pulmonary MRI (1R21HL168430-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10984522. Licensed CC0. --- *[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*