# Admin supplement - Autism in young children with Down Syndrome

> **NIH NIH R01** · COLORADO STATE UNIVERSITY · 2024 · $423,143

## Abstract

Abstract
Down syndrome (DS) is associated with an elevated likelihood of co-occurring psychiatric conditions, including
autism spectrum disorder (ASD). At present, little is known regarding the mechanisms that underly co-occurring
DS and ASD. Advancing the scientific knowledge base in this area could facilitate the potential discovery of
measurable biomarkers associated with early identification of ASD risk and also inform groundbreaking
biomedical treatments targeting underlying molecular processes. This Administrative Supplement will expand
the scope of parent project #R01HD110542 (Autism in Young Children with Down Syndrome) to identify early
biosignatures associated with early ASD-related dimensions in young children with DS. To do so, this project will
build on the parent study’s prospective design by collecting blood samples concurrently with study visits, and
examine the link between early ASD features and multi-omics signatures in the transcriptome, proteome, and
metabolome. Findings from the proposed Administrative Supplement project could facilitate the potential
discovery of measurable biomarkers associated with early identification of ASD risk and inform groundbreaking
biomedical treatments targeting underlying molecular processes. This study expansion will directly address the
NIH INCLUDE objective of identifying the “unique combination of risk and resiliencies [to] inform medical
advances for individuals with Down syndrome” and to improve health and well-being in this population.

## Key facts

- **NIH application ID:** 10984657
- **Project number:** 3R01HD110542-02S1
- **Recipient organization:** COLORADO STATE UNIVERSITY
- **Principal Investigator:** Joaquin M. Espinosa
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $423,143
- **Award type:** 3
- **Project period:** 2023-09-01 → 2028-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10984657

## Citation

> US National Institutes of Health, RePORTER application 10984657, Admin supplement - Autism in young children with Down Syndrome (3R01HD110542-02S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10984657. Licensed CC0.

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