SUMMARY The goal of this proposal is to enable a comprehensive modernization of an aging system in the shared zebrafish research facility in Bevis Hall at the Ohio State University. The modernization proposal will align the capabilities of the zebrafish facility with modern demands on zebrafish science and increase capabilities to allow affiliated researchers to consider experiments that were previously unattainable. The zebrafish facility in Bevis Hall houses the fish of three core- and five additional users. The research supported by this facility spans neural development, heart regeneration, systems neuroscience, cancer research and nutrition. The renovation will allow automatic monitoring and control of critical water parameters and automatic feeding. These advances will increase research reproducibility, reduce waste, and dramatically shorten generation time. The expected reduction in size and growth variability of adult and juvenile zebrafish will allow for new research avenues in these stages. The decrease in time from hatching to sexual maturity of zebrafish will increase the amount of generated transgenic and mutant fish available to researchers at The Ohio State University and beyond. The proposed modernization will also centralize water filtration and eliminate food-waste, reducing the environmental footprint of the facility. Increasing the reproducibility of experiments through better controlled feeding and water parameters will allow reducing the amount of animals used in experiments.