The Federation of American Societies for Experimental Biology (FASEB) proposes a MOSAIC program that will provide diverse scholars from historically excluded groups in biological and biomedical research with professional skills needed to establish a successful academic career, coupled with mentoring, cohort support, network development, and the fostering of resilience. This support will increase scholar retention in academic research, thus diversifying the biomedical research enterprise and contributing to long-term improvements in inclusive research environments at institutions and within scientific societies. In turn, this will lead to advancements in health research outcomes due to the benefit of diverse perspectives brought to the effort to address scientific challenges. FASEB has deep organizational experience in providing support to early-career researchers. The project’s goals are to prepare five cohorts of diverse early-career researchers (postdocs progressing to independent faculty) in research team management and provide support through training, mentoring, and networking, leading to the MOSAIC scholars’ ability to persist in career advancement while maintaining well-being through empowerment and resilience. Specific aims are to (1) develop research management skill sets in diverse postdoctoral and early-career faculty researchers by leveraging FASEB’s deep network of experts and mentors across scientific societies, as evidenced by scholar capabilities in setting up a lab and progressing in research; (2) develop resilience in diverse postdoctoral and early-career faculty researchers through identity development based on competence, performance, and recognition, as evidenced by increased scholar confidence to overcome barriers and achieve stage-appropriate research career progression both institutionally and through professional service; and (3) create sustaining support systems that involve skills development, peer support, and safe spaces, as evidenced by scholar perceptions of the value of such support in helping them persist in their career pathway while maintaining resilience and well-being. FASEB’s MOSAIC program will implement a professional development series that covers skill sets important for facilitating scholar career progression. The series covers foundational skills, professional skills, effective grant writing, and academic career planning over four years. Resilience will be covered in a resilience and self- advocacy course and through virtual support spaces. In a multi-mentor model, the scholars will be matched with a mentor identified through FASEB’s extensive network to complement the mentoring they receive through their home institutions. Mentoring will cover career issues, professional management, and work-life balance and will foster the development of professional networks. Additional activities include financial support for conference attendance; engagement of leaders at the scholars’ home institutions to align ef...