The mission of the Pittsburgh Center for Training in Kidney, Urology and Hematology (PCT-KUH) is to develop the next generation of KUH investigators. This training program will prepare predoctoral students, physicians and PhDs for biomedical research careers by providing a concentrated, in-depth research experience. The program is designed to foster a rigorous approach to scientific inquiry in basic science or clinical investigation. Three areas of research are emphasized: kidney, urology and benign hematology. Trainees will develop a research project under the close supervision of a faculty trainer and will be closely monitored by an independent advisory or dissertation committee, as well as by the research training executive committee. An intensively structured research experience will be supplemented by didactic lectures, research seminars, journal clubs, formal course work, attendance at scientific meetings, and structured professional development and networking cores. Professional development will encompass opportunities to develop skills in grant writing, scientific communication and team science, facilitate career development and resilience, and provide mentor training. The network core will build a robust community of learners in the KUH space around already existing training programs in the Pittsburgh region and the trainees funded by PCT-KUH, and enhance community outreach to attract diverse individuals to careers in biomedical science. Predoctoral graduates of this comprehensive training experience will be equipped to compete for individual training support. Postdoctoral graduates of this program will be prepared to compete for independent funding and entry-level faculty positions in academic medicine and industry.