Professional Development Core Abstract The overall goal of the Pittsburgh Center for Training in Kidney, Urology and Hematology (PCT-KUH) Professional Development Core is to develop and support curriculum, activities opportunities and resources designed to equip trainees with career development skills that will be sustained well past the training period. Our primary directive is to provide trainees with the information and resources they need to identify, pursue, and be impactful in a broad range of career paths that will benefit from their scientific training. At the same time, this core will provide professional development resources for faculty mentors to enhance their mentoring skills in order to have highly effective mentor-mentee relationships. We have assembled an experienced and diverse leadership and facilitator structure, a well-rounded curriculum and a supporting learning environment that leverages the rich resources at the University of Pittsburgh, Carnegie Mellon University and Allegheny Health Network for professional growth and career exploration. Our specific objectives are: Objective 1: Impart transformational knowledge, investigative and grant writing Skills. Build trainees' opportunities to acquire new investigative skills and ability to frame testable hypotheses, and prepare trainees to plan, secure funding for, conduct, analyze, publish, and promote implementation of significant, rigorous high-quality, reproducible research. Objective 2: Facilitate career development, exploration and planning. Strategically position trainees to meet evolving challenges and provide opportunities for career exploration and adaptability. Objective 3: Build skills for forging productive partnerships, networking and communication. Train students to generate and refine ideas in partnership with stakeholders, work effectively in teams, communicate to and learn from diverse audiences, and convey the joy of discovery. Objective 4: Build skills for trainee resilience and promote wellness Empower trainees to develop intellectual and emotional resiliency to adapt to new scientific and professional environments. Objective 5: Enhance mentor training. to ensure highly productive and effective mentee/mentor relationships. We have designed a program that will support trainee's and mentors' leadership, team building and career development. Most importantly, our trainees, faculty, career coaches, and their peers and near-peers will foster lifelong strategies and habits that promote career satisfaction, professional growth, team science, leadership, inclusivity, resilience and plasticity.