PROJECT SUMMARY/ABSTRACT The objective of this Diversity Supplement is to support an 18-month postbaccalaureate research experience for Rohda Yase. Ms. Yase is a bachelor’s degree candidate who will be applying to enter into an MD-PhD program in the fall of 2026. The goal of the parent grant (R01 AR074417) is to understand genetic risk factors for osteoporosis to identify new drug targets to reduce this massive health burden. Ms. Yase’s work will supplement SA1 of the parent grant, which is to identify novel genes regulating bone mass and mineral accrual at bone mineral density (BMD)-associated loci in a reverse genetic screen. In SubAim1B, we proposed to generate and characterize germline loss-of-function mutants for six genes. The proposed work for this diversity supplement research project will add a seventh gene to SubAim1B. This gene is related to, but distinct from, the genes being tested in the parent grant. The career development plan, which includes access to a network of scientific, career, and clinical mentors, attendance of national conferences, and preparatory coursework, is tailored to Ms. Yase’s career goal of obtaining an MD-PhD and becoming a physician-scientist. In regard to the training environment, the PI has a successful record of mentoring individuals with similar career goals as Ms. Yase, and has demonstrated his commitment to advancing diversity, equity, and inclusion in the biomedical sciences through outreach, mentorship, and service. The expected impact of this project is that Ms. Yase will gain skills, experience, and mentorship that grant her new research independence and increase her competitiveness for the most competitive MD-PhD programs.