PROJECT ABSTRACT This supplement application is for the purchase of a 3-color Optos ultra-widefield (UWF) scanning laser ophthalmoscope (SLO). The Optos SLO is the current state of the art for wide angle retinal imaging and is widely used. Numerous studies have shown the advantages of UWF imaging for diagnosis of retinal diseases. The previous generation Optos only used a red and green laser to image the retina causing poor color representation and introducing unique artifacts. These limitations have been overcome by the introduction of the red, green, blue (RGB) 3-color laser UWF Optos. We have evaluated this instrument in the Jacobs Retina Center and in our department. The new RGB 3- SLO color instrument provides images closer to the true color of the retina. In our comparative study we imaged 75 eyes of 45 patients with four different instruments (Topcon fundus camera, RGB 3- color Optos, RG 2-color Optos and the multicolor Spectralis OCT). We cropped the images to identical field-of-view to avoid any image shape bias and in a masked study compared each of the three SLO devices to the gold standard color fundus camera in the ability to make a clinical diagnosis. We found that the RGB 3-color Optos is superior to the conventional RG 2-color Optos and the multicolor Spectralis. We wish to purchase the RGB 3-color UWF Optos to permit our AI retina research to continue with the state-of-the-art instrument. Note that our studies are already covered by the IRB as we have a retina registry which permits use of de-identified images and in addition all patients sign consent for ophthalmic examination and imaging when checking in to UCSD Ophthalmology.