# Duke-Utah HEAL KIDS Pain Resource and Data Center

> **NIH NIH U24** · DUKE UNIVERSITY · 2024 · $724,981

## Abstract

PROJECT SUMMARY/ABSTRACT
Thousands of children in the United States receive treatment for acute pain each year, and even more
experience pain that is unrecognized. The majority of those who are treated receive interventions that have not
been proven to be safe or effective in children. Inadequately treated acute pain can lead to chronic pain and
multiple adverse outcomes. Rigorous trials performed under a structured research and data ecosystem that
address acute pediatric pain are urgently needed. To address this critical, unmet public health need, we will
establish the Duke-Utah HEAL Kids Pain Resource and Data Center (Duke-Utah RDC). Our RDC will support
multi-site clinical trials within the HEAL KIDS Acute Pain Clinical Trials (APCT) with the overarching goal of
harmonizing these trials in an integrated program with shared objectives, procedures, and tools to maximize
knowledge gained in pediatric pain. The Duke University Clinical Research Institute (DCRI) and The University
of Utah, two powerhouses in clinical trial and data coordination with an established history of collaboration, are
uniquely positioned to establish this RDC. We will leverage the capacity and experience of the world’s largest
academic research organization, DCRI, and the pediatric trial and informatics expertise of the Utah DCC to
integrate high-quality logistics and operations, experienced communications management, and sophisticated
data and informatics solutions for the HEAL KIDS program. The faculty on our proposal, who include
pediatricians with subspecialty expertise (Greenberg, Benjamin, Watt) and experts in informatics (Sward), will
provide coordination, support, and consultation to HEAL KIDS program investigators and trial data coordinating
centers, building their capacity to implement well-designed, efficient trials that produce high-quality, easily
accessible data. To achieve this vision, we will establish 2 RDC cores: 1) a Data Curation and Harmonization
Core; and 2) an Administrative and Communications Core. These cores will engage proactively with the ACPT
trial teams, data coordinating centers, NIH, and other stakeholders to accomplish the following specific aims: 1)
Create and sustain a harmonized HEAL KIDS Pain research and data ecosystem; 2) Facilitate compliant data
sharing and seamless accessibility to maximize future research; and 3) Support effective communication within
the program and to the broader research community. Our HEAL KIDS Pain research and data ecosystem will
lay the foundation for the generation of harmonized data. We will ensure that these data are submitted to
public use repositories and easily accessible to investigators through the use of sophisticated informatics tools.
The Duke-Utah RDC will fuel the successful completion of the awarded APCT trials while maximizing the
impact of the resulting data to ensure forward progress in the management of pediatric pain conditions. Our
infrastructure will serve as a model and foundation for ...

## Key facts

- **NIH application ID:** 10990605
- **Project number:** 1U24HD116261-01
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** DANIEL K. BENJAMIN
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $724,981
- **Award type:** 1
- **Project period:** 2024-09-04 → 2030-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10990605

## Citation

> US National Institutes of Health, RePORTER application 10990605, Duke-Utah HEAL KIDS Pain Resource and Data Center (1U24HD116261-01). Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/grant/nih/10990605. Licensed CC0.

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