PROJECT SUMMARY/ABSTRACT Because cardiovascular disease (CVD) affects 1 in 2 US adults, burdens disadvantaged groups, and incurs high costs, the need to identify new prevention targets, their mechanisms, and effective interventions is great. Like CVD, insomnia afflicts millions of US adults, burdens disadvantaged groups, and incurs high costs. Moreover, insomnia is an independent, and likely causal, risk factor for CVD. Although candidate biological mechanisms through which insomnia may promote CVD development have been identified, candidate behavioral mechanisms have received less attention. Unhealthy eating behaviors – e.g., emotional eating, external eating, restrained eating, poor diet quality, and night eating – are promising candidate behavioral mechanisms due to their links with sleep disturbance and CVD risk. To date, little research has assessed the relationships between objective sleep parameters and unhealthy eating behaviors, examined unhealthy eating behaviors as mediators of sleep disturbance-CVD risk relationships, or explored sociodemographic factors as moderators of these relationships. In this Diversity Supplement to the recently funded SHADES mechanistic trial (R01 HL165115), we propose an observational ancillary study to address these knowledge gaps. The proposed study will utilize data collected from a diverse sample of 200 primary care patients with insomnia from a large safety net healthcare system. We will examine eating behavior data (to be acquired through this supplement) and baseline data from the SHADES trial (to be acquired through the parent award) to achieve the following specific aims: (1) assess relationships between objective sleep parameters and unhealthy eating behaviors; (2) assess relationships between unhealthy eating behaviors and CVD risk biomarkers; (3) examine if unhealthy eating behaviors mediate relationships between sleep parameters and CVD risk biomarkers; and (exploratory) explore whether the relationships of interest are moderated by sex, race, or socioeconomic status. Filling these knowledge gaps will advance understanding of the mechanisms underlying the insomnia- to-CVD relationship, could identify novel targets for interventions designed to lower CVD risk in people with insomnia, and could inform future tailored interventions. The candidate for this supplement is Timothy Lipuma, a qualified and promising graduate student in IUPUI’s Clinical Psychology PhD program. Through the proposed activities and under the mentorship of Dr. Jesse Stewart (PI of the parent trial), Mr. Lipuma will achieve the following training goals: (1) increase knowledge and experience in the design and conduct of clinical trials in primary care settings, (2) increase knowledge of insomnia screening and treatment and CVD risk screening and management in primary care settings, and (3) further develop leadership ability and skill set. Completing the proposed activities will pave the way for Mr. Lipuma to achieve his long-ter...