ABSTRACT Latinx children in the United States (US) are more than 50% more likely to die of their cancer diagnosis in comparison to non-Latinx White children due to systemic inequities which arise from adverse social determinants of health (SDOH). Latinx families in the US face several adverse SDOH including discrimination based on race/ethnicity, language, or culture, and inequitable social structures that limit their access to various resources, all of which affects their child’s risk of developing and dying from cancer and aggravate bereavement and grief inequities among family members, including depression, anxiety, post-traumatic stress disorder, and social isolation. Despite higher cancer mortality, there remains a striking under representation of Latinx populations in the study of pediatric bereavement. Further, the identification of resiliency factors has remained undiscovered because the experience of cancer loss in Latinx populations has not yet been explored from a culturally and contextually grounded, strength-based perspective. The overall purpose of this study is to explore the culturally grounded experiences and grief outcomes of Latinx families in the US who are living through the loss of a child to cancer. This study will utilize a modified version of the Center for Latino Adolescent and Family Health Framework of SDOH Mechanisms, that has been integrated with culturally grounded grief concepts in a mixed methods design that integrates data from validated measures representing the framework’s domains (n=60), with qualitative descriptive data from individual interviews (n=~20) with the deceased child’s primary caregiver. The aims are to: Aim 1: To examine relationships among the domains of the SDOH mechanisms of Latinx families in the US who are living through the loss of a child to cancer including SDOH capital (healthcare access), SDOH processes (acculturation stress), contextual exposures (social meaning-making), resiliency factors (Latinx culture) and critical grief outcomes (coping, mental health, post-traumatic growth, continuing bonds) through self-reported measures. Aim 2: To elucidate the experiences of Latinx families in the US who are living through the loss of a child to cancer in the context of SDOH mechanisms (SDOH capital, SDOH processes, contextual exposures, resiliency factors, critical grief outcomes) through in-depth, individual semi-structured qualitative interviews. Aim 3: To develop a comprehensive understanding of how multilevel resiliency factors across the domains of SDOH mechanisms (healthcare access, acculturation stress, social meaning-making, culture, critical grief outcomes) influence adaptive grief outcomes among Latinx families in the US after the loss of a child to cancer by integrating data from self-reported measures and qualitative interviews. The findings will enhance the understanding of the mechanisms of inequities in pediatric oncology bereavement outcomes that can affect Latinx bereaved fami...