# C. elegans models of metabolism in health and disease

> **NIH NIH R01** · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $683,322

## Abstract

Metabolism lies at the heart of most if not all biological processes to generate biomass during
development and in wound healing, to generate energy to support cellular and organismal processes,
and to detoxify exogenous and endogenous toxic compounds. We will study metabolic perturbations
using gene mutants and metabolite supplementations on physiological and molecular phenotypes in
the nematode C. elegans and examine the effect of bacterial diet on these phenotypes. We will focus
on perturbations associated with inborn errors of metabolism (IEMs), which are human metabolic
disorders that are caused by mutations (usually recessive) in metabolic enzymes and transporters. This
work will shed light on the basic mechanisms of how an animal responds to different metabolic
perturbations and how environmental factors such as diet and microbiota modulate them. These studies
may further provide hypotheses relevant for studies in larger eukaryotes, including humans.

## Key facts

- **NIH application ID:** 10994241
- **Project number:** 2R01DK068429-18A1
- **Recipient organization:** UNIV OF MASSACHUSETTS MED SCH WORCESTER
- **Principal Investigator:** A. J. Marian Walhout
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $683,322
- **Award type:** 2
- **Project period:** 2005-05-01 → 2028-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10994241

## Citation

> US National Institutes of Health, RePORTER application 10994241, C. elegans models of metabolism in health and disease (2R01DK068429-18A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10994241. Licensed CC0.

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