Project Summary/Abstract The Human Tumor Atlas Network (HTAN) seeks to improve our understanding of the important transitions during tumorigenesis, progression, and metastasis, and to provide a detailed, multi-dimensional map of these states. Since 2018, our multi-institutional group has managed the HTAN Data Coordinating Center (DCC), and HTAN data are now available via multiple mechanisms, including the HTAN Data Portal, the Synapse platform, and the NCI Cancer Research Data Commons (CRDC). The aim of this application is to continue the important work of the DCC by continuing to release HTAN data to the wider scientific community and further developing visualization, annotation, and analysis tools that meet the needs of HTAN and the diverse cancer research community. Our vision for the HTAN DCC is a dynamic, modular and adaptive center that will: 1) continue to evolve the HTAN data standards, and continue to build and maintain the core HTAN data platform for storage, analysis, and dissemination; 2) continue to provide logistical support for network coordination and communication; and 3) expand our education and outreach activities to the wider scientific community, further enabling the re-use of HTAN data.