PROJECT SUMMARY/ABSTRACT The University of Rochester, Wilmot Cancer Institute is a health and research institute ideally suited to achieve the goals of the NCI NCTN as a Lead Academic Site to improve the lives of people with cancer. Our longstanding activity as U10-funded members of ECOG (1968-2002) and SWOG (2002-2012) as well as our dedication to NCTN trials over the past 5 years indicate our continued investment in and commitment to clinical and translational laboratory research in cancer, particularly the development of and accrual to late-phase Cancer Clinical Trials. In an era where both the biology of cancer and development of novel therapeutic strategies have become more complex, requiring multidisciplinary teams of investigators and extensive tissue banking and correlative studies, our translational scientific program and dedication to the NCTN program is critical for ultimate success.