# Revision to Mechanisms of accelerated calcification and structural degeneration of implantable biomaterials in pediatric cardiac surgery

> **NIH NIH R01** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $569,377

## Abstract

Summary
We are proposing a competitive revision for R01 HL163085, that will address in vitro and ex vivo the contribution
of systemic vs pulmonary circulation conditions on the mechanisms of structural degeneration of implanted
biomaterials for left and right side cardiac reconstruction approaches.
Congenital heart defects (CHDs) affect nearly 1% of?or about 40,000?births per year in the United States. More
than 40% of CHD patients require the replacement of one of the valves. Congenital lesions of any of the heart
valves are associated with a wide spectrum of cardiac malformations, impacting both the left and right side of the
heart. Left-side anomalies may involve any component of the Aortic or Mitral valve apparatus that result in stenosis,
regurgitation, or mixed hemodynamic disturbances. In adulthood, common diseases of the mitral valve include
degenerative mitral regurgitation (DMR) and ischemic mitral regurgitation (IMR), for the Aortic Valve, Aortic
Insufficiency (AI), or stenosis. Several CHD primarily affect the right heart including Tetralogy of Fallot,
transposition of great arteries, septal defects leading to pulmonary vascular disease, Ebstein anomaly and
arrhythmogenic right ventricular cardiomyopathy.
For both Left and Right sided CHD reconstructive surgeries, the biomaterials have several important limitations,
impacting long-term biocompatibility and durability. The primary goals of the parent award HL 163085 are: to
understand the mechanisms of accelerated structural degeneration of implantable biomaterials in pediatric and
young adults by assessing the role of protein absorption on implanted biomaterials and to test mitigation strategies
to extend the lifespan of these biomaterials in vitro, ex vivo, and in vivo by using juvenile and adult rat models. In
this revised supplement we address how systemic vs pulmonary circulation conditions (including the different blood
biochemistry and hemodynamic conditions) is impacting the materials used for reconstructive heart surgery.

## Key facts

- **NIH application ID:** 10994890
- **Project number:** 3R01HL163085-02S1
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Giovanni Ferrari
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $569,377
- **Award type:** 3
- **Project period:** 2023-04-01 → 2027-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10994890

## Citation

> US National Institutes of Health, RePORTER application 10994890, Revision to Mechanisms of accelerated calcification and structural degeneration of implantable biomaterials in pediatric cardiac surgery (3R01HL163085-02S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10994890. Licensed CC0.

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