# Enhancing Surveillance Spirometry of At-Risk Occupationally Exposed Populations

> **NIH ALLCDC U01** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $349,999

## Abstract

Project Summary
 Our long-term goal has been to characterize the heterogeneous group of chronic lower airway diseases
(LAD) observed in World Trade Center (WTC) workers and volunteers, uncover their risk factors and
comorbidities, identify subgroups with adverse and favorable lung function trajectories and outcomes, deploy
novel imaging approaches to the investigation of the underlying lung injury, and improve surveillance and
prevention strategies.
 Our previous research suggests the differential adverse effects and imaging characteristics of the
longitudinal lung function trajectories of the WTC workers, and markers suggesting early chronic disabling lung
disease. We thus propose to test the use of added respiratory surveillance tools and explore functional
markers of disease progression, explore alternate methods to investigate longitudinal functional trajectories,
and novel spirometry calibration methods that might facilitate the implementation of spirometry in
nonspecialized settings.
 This project will be conducted in the occupational cohort followed at Mount Sinai, among the WTC
Pulmonary Evaluation Unit Chest CT Imaging Archive subcohort members still on active health surveillance.
This group of 1710 WTC workers has detailed disease symptom, both pre-WTC and WTC-related
occupational exposure, longitudinal spirometry measurements and body weight trends, visual chest CT
imaging classification and grading, and quantitative computer tomography (QCT) measurements of airway,
body composition, and pulmonary parenchymal and vascular abnormalities.

## Key facts

- **NIH application ID:** 10995057
- **Project number:** 1U01OH012782-01
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Rafael E. de la Hoz
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** ALLCDC
- **Fiscal year:** 2024
- **Award amount:** $349,999
- **Award type:** 1
- **Project period:** 2024-07-01 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10995057

## Citation

> US National Institutes of Health, RePORTER application 10995057, Enhancing Surveillance Spirometry of At-Risk Occupationally Exposed Populations (1U01OH012782-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10995057. Licensed CC0.

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