Abstract During development, networks between neurons must be established and maintained, with unnecessary neurons requiring timely removal. The contributions of astroglia to these developmental processes are only just being explored. The zebrafish optic tectum (OT), the major visual processing center, is a common model for investigating neural circuitry. Using in vivo, time-lapse imaging of Tg(slc1a3b:myrGFP-P2A-H2AmCherry) transgenic larvae, I observed OT radial astroglia extending projections from their pial processes basally towards the ventricular zone. These small processes often formed large spherical structures, measuring approximately 5 micrometers in diameter and lasting up to 10 hours before dissipating. Currently, the identity and function of these projections are unclear. Using molecular characterization, we have begun assaying the nature of this developmental phenomenon. From my preliminary data, at least some of the spherical structures contain dying neurons. I also observe these structures interacting with microglial processes, with microglial processes invading the structures to remove their contents (i.e. dying neurons). Due to their shape, size, movement, and engulfment of other cell nuclei, I tentatively dub these structures “scyllate heads”, in reference to the multi-headed Odyssean figure Scylla. Due to an observed association with microglia, I hypothesize that scyllate heads sequester developmental debris, including exuberant neurons, for later phagocytosis by professional phagocytes. Here I propose a project to describe scyllate heads, discern their function in OT development, and explore their interactions with other cell types.