# Viral Infection and Inflammation Workshop 2024

> **NIH NIH R13** · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $7,000

## Abstract

ABSTRACT
 Acute and chronic effects of viral diseases often involve immune-mediated responses, including
inflammation, immune activation, and autoimmunity. Long-COVID immunopathogenesis is complex but its
understanding is advancing rapidly. The consequences of immune-mediated damage in long COVID share
similarities (and differences) with other post-viral diseases like Ebola and myalgic encephalomyelitis/chronic
fatigue syndrome (ME/CFS). In the case of HIV, ongoing activation of the inflammatory response is a major
concern, and immune reconstitution remains limited in some patients even long after treatment initiation. In
addition to SARS-CoV-2 and HIV, other viral infections such as CMV are known to result in inflammation-
related pathology. Viruses can also trigger autoimmunity. Epstein-Barr Virus is tightly linked with the onset of
Multiple Sclerosis through several autoimmune mechanisms. Viral encephalitis also often has an autoimmune
background. Common underlying mechanisms imply the possibility of employing similar therapeutic
interventions, such as neutralizing antibodies, antiviral drugs, and therapeutic vaccines to eliminate the
persistent virus or anti-inflammatory drugs to ameliorate chronic inflammation. Therapeutic interventions must
often target both ends of the virus-immune system spectrum. The prevalence of post-acute infectious
syndromes is concerning. The severity of the syndrome disables daily activities, posing a significant burden on
health, economy, and society. Despite intensive research on cellular and molecular mechanisms, scientific
platforms to share data and discuss new concepts are limited to sessions at major international conferences or
scientific meetings focusing on a specific condition.
 This annual workshop links leading international scientific investigators in a discussion of cutting-edge
research developments on underlying inflammatory mechanisms related to viral infection, and its clinical
implications. Specific aims of the meeting include: 1) providing a global cross-disciplinary platform to exchange
knowledge on underlying mechanisms of virus-mediated inflammation; 2) gathering basic, translational, and
clinical researchers, and clinicians to stimulate discussion on remaining unknowns; 3) fostering future
collaborations among participants; 4) translating the data into clinical guidance; and 5) increasing the visibility
of early career investigators and investigators from underrepresented minority (URM) groups and their
research, thereby facilitating a generation of future leaders in the field.

## Key facts

- **NIH application ID:** 10997471
- **Project number:** 1R13AI186262-01
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** Daniel R. Kuritzkes
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $7,000
- **Award type:** 1
- **Project period:** 2024-07-17 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10997471

## Citation

> US National Institutes of Health, RePORTER application 10997471, Viral Infection and Inflammation Workshop 2024 (1R13AI186262-01). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/10997471. Licensed CC0.

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