Abstract Summary Biocompatibility testing of the COSMIIC System The aim of this supplement is to conduct biocompatibility testing of the COSMIIC System components, under currently accepted standards (ISO 10993-1), and to make the testing procedures and results available to the public under our open source licenses. The Specific Aims of this supplement are: Specific Aim #1 Complete a Q-Sub with the FDA to gain insights into biocompatibility requirements for a device covered in an Early Feasibility Study (EFS) Investigational Device Exemption (IDE). Specific Aim #2 Generate a comprehensive Biological Evaluation Report (BER). Specific Aim #3 Develop a toxicology risk assessment based on chemical characterization and test results. Specific Aim #4 Publish all test procedures (to the extent allowable) and all test results freely available under the COSMIIC open source licenses.