# Investigating Impacts of Neighborhood Disadvantage on ADRD risks, imaging biomarkers, and cognition

> **NIH NIH F30** · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2024 · $53,974

## Abstract

PROJECT SUMMARY
An estimated 6.7 million Americans are living with Alzheimer’s disease (AD) dementia in 2023, with more than
55 million people living with AD worldwide. However, stark disparities exist in the prevalence of AD with older
adults with multidimensional poverty being more than twice as likely to develop dementia during their lifetime.
Resources, opportunities, and the environment where you live, work, play, and age, also known as the social
determinants of health, have been proposed as significant predictors of numerous risk factors associated with
dementia. This proposal will investigate the influence of a novel social determinant of health, neighborhood
disadvantage, on (1) cardiovascular and metabolic risk factors, brain imaging biomarkers, and (2) cognitive
function associated with AD and related dementias (ADRD). This project will utilize data from the Wake Forest
Alzheimer’s Disease Research Center (ADRC) Clinical Core Cohort to conduct analyses investigating these
relationships. Training will take place at the Wake Forest University School of Medicine in the Molecular
Medicine and Translational Science (MMTS) and Medical programs as a part of the M.D./Ph.D. dual-degree
program. The applicant will receive training in the foundational knowledge necessary to conduct health
disparities research, statistical methodology and analytical design, and scientific writing and communication to
accomplish the proposed aims. Mentorship for the proposal includes a multidisciplinary team with individuals in
the ADRC, along with faculty in the Internal Medicine and Neurology departments. This team will provide the
applicant with feedback every step along the way, regarding data analysis, interpretation of findings, and
manuscript preparation. The proposed aims have the potential to provide new insights into the effects of one’s
neighborhood-level disadvantage on various factors of risk associated with ADRD and further elucidate the
influence of social determinants of health on risk for dementia.

## Key facts

- **NIH application ID:** 10998527
- **Project number:** 1F30AG085932-01A1
- **Recipient organization:** WAKE FOREST UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Sudarshan Krishnamurthy
- **Activity code:** F30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $53,974
- **Award type:** 1
- **Project period:** 2024-09-01 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10998527

## Citation

> US National Institutes of Health, RePORTER application 10998527, Investigating Impacts of Neighborhood Disadvantage on ADRD risks, imaging biomarkers, and cognition (1F30AG085932-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10998527. Licensed CC0.

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