Project Summary/Abstract The specific aims of this FASEB Science Research Conference are to present and discuss the most current work on 1) the critical roles of nutrients and metabolism in mediating development and aging, 2) how nutrient sensing and signaling are improperly regulated in diseases, 3) innovative experimental approaches and tools to measure and manipulate metabolism and, 4) how altering nutrient sensing and signaling can be leveraged as potential therapy. This meeting will be the tenth in a series which has for the past 30 years successfully promoted interdisciplinary discussion and collaboration among research scientists and physician-scientists in fields related to obesity, diabetes, nutrition, and exercise across the life span. This meeting continues its proud legacy of encouraging the attendance and participation of scientists who are Early-Stage and/or underrepresented in biomedical research. 23 established investigators and 13 Early-Stage investigators will serve as invited speakers. Poster sessions will permit all participants to contribute, and an additional poster competition will provide special attention and recognition for research efforts by trainees. Dr. Scot Kimball, PhD, an international expert in nutrient sensing and signaling in metabolism, will deliver a keynote address on skeletal muscle signaling and metabolism, followed by a session on the interaction of nutrients and exercise in maintenance of skeletal muscle metabolic homeostasis. Eight additional sessions will broadly address current topics in nutrition and metabolism in a variety of body tissues and the microbiome, all aimed toward prevention or treatment of metabolic diseases such as obesity, diabetes, sarcopenia and cachexia. Every session also includes speaking opportunities for abstract submissions and poster competition winners. A career development panel for trainees is included in the agenda and financial support for family care will also be available. The total number of participants will be limited to 200 to encourage interaction and increase the opportunity for trainees to meet and discuss research with senior scientists. The five-day meeting will be held August 4-8, 2024, in Southbridge, Massachusetts.