# Exploiting somatotopy within the cervical vagus in a chronic large animal model

> **NIH NIH U41** · CASE WESTERN RESERVE UNIVERSITY · 2024 · $86,273

## Abstract

Abstract Summary
Vagus Nerve Somatotopy using the COSMIIC System
 In this Supplement, we will use the COSMIIC Platform System components to assess the
impact of chronic fibrous encapsulation on evoked recording from the cervical vagus nerve
immediately post-implant and chronically over time. Recent studies have provided basic proof
of concept that smaller, multi-contact electrodes may stimulate specific portions of the cervical
vagus to selectively activate intended therapeutic pathways while minimizing co-activation of
off-target pathways. These studies were performed acutely under anesthesia. In this
supplement, we intend to leverage the HORNET system for chronic stimulation and recording to
develop pilot data to address these gaps. The aims of this supplement are: 1) assess the impact
of chronic fibrous encapsulation on evoked emg, eng, and physiological responses over time
with continuous stimulation started immediately post-implant, and 2) assess the impact of
chronic continuous stimulation started 1-month post-implant on evoked emg, eng, and
physiological responses over time.

## Key facts

- **NIH application ID:** 10998817
- **Project number:** 3U41NS129436-02S4
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **Principal Investigator:** Cynthia Anne Chestek
- **Activity code:** U41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $86,273
- **Award type:** 3
- **Project period:** 2024-05-01 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10998817

## Citation

> US National Institutes of Health, RePORTER application 10998817, Exploiting somatotopy within the cervical vagus in a chronic large animal model (3U41NS129436-02S4). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10998817. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*