PROJECT SUMMARY The objective of this proposal is to provide financial support for the inaugural "Vasoregulation: Signaling and Multicellular Inputs" FASEB Scientific Research Conference (SRC) scheduled for August 4-8, 2024, at the Loews Ventana Canyon Resort in Tucson, Arizona, USA. The conference focuses on vasoregulation, the physiological process responsible for regulating the diameter of small muscular arteries and arterioles to maintain optimal blood flow and blood pressure. Dysfunctional vasoregulation is associated with numerous cardiovascular disorders, including hypertension, atherosclerosis, small vessel diseases, and other pathologies. Discovering important physiological and pathological elements of essential vasoregulatory processes will significantly contribute to our understanding of cardiovascular health and disease. Derived from the successful Smooth Muscle FASEB SRC series held triennially from 1982 to 2019, the 2024 Vasoregulation conference acknowledges the evolving research landscape emphasizing the roles of endothelial cells, pericytes, astrocytes, neurons, and other factors in the regulation of vascular smooth muscle contractility. Our new name and format reflect this shift, encompassing intercellular regulatory mechanisms alongside smooth muscle functionality. The conference promotes inclusive engagement, encouraging participation from diverse disciplines such as genetics, neuroscience, and biophysics, enriching intellectual discourse and scholarly exchange. The event will be a pivotal platform for disseminating cutting-edge research findings, fostering mentorship initiatives, and cultivating collaborative networks within the vascular regulation community. The meeting will be co-organized by Dr. Jonathan Jaggar, Dr. Scott Earley, and Dr. Madeline Nieves-Cintron. Dr. Anne Joutel, renowned for discovering the molecular basis of a common genetic form of cerebral small vessel disease, will deliver the keynote lecture. The conference will include eight thematic platform sessions, two poster sessions, and two crucial career development activities aimed at early-stage investigators. The scientific sessions prioritize diversity, with 44.2% women, 32.6% underrepresented minorities, and 25.6% early-stage investigators among the 43 invited speakers. Short talks selected from abstracts submitted by early-stage researchers contribute to a balanced blend of established experts and promising investigators, representing a global cross-section from North America, Europe, and the UK. This medium-sized conference (~100 attendees) emphasizes informal discussions during various activities to encourage collaboration, particularly among early-stage scientists. To ensure broad participation, the organizers aim to subsidize registration and travel costs for trainees and early- stage investigators, particularly women and underrepresented minorities, using support provided by NIH/NHLBI.