ABSTRACT Support is requested for a Keystone Symposia conference entitled Positive Strand RNA Viruses: Interdisciplinary Advances in Virology, Pathogenesis, Immunology, and Technology Development, organized by Drs. Kizzmekia Corbett-Helaire, William Klimstra and Jolanda Smit. The conference will be held in Killarney, Ireland from October 21–25, 2024. Positive-strand RNA viruses have proven to be an impactful global health priority that is experiencing a unique moment, which is fueled by the momentum of the COVID-19 pandemic and driven by the influx of new knowledge and technologies. Successful scientific breakthroughs in this area are the result of advances in basic virological understanding and molecular genetics, merged with other fields such as human immunology, structural biology, and vaccine development. Together, these alignments have opened new multidisciplinary frontiers and created exciting opportunities for virology research. This conference will take a tour of new knowledge in positive-strand RNA virology starting with virus-host interactions and ending with technological and clinical development. The interdisciplinary nature of the conference will provide novel insights across virology, viral immunity, vaccinology and more. In addition, the conference will feature a diverse array of positive-strand RNA viruses, including understudied viruses, revealing common themes and distinctions that might be leveraged for clinical utility. Throughout the conference, new and emerging young investigators will be highlighted alongside field leaders to bring forth new ideas and perspectives for discussion that will advance the field in innovative directions.