# Metabolic Resuscitation in Heart Failure.

> **NIH NIH R01** · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · 2024 · $748,829

## Abstract

PROJECT DESCRIPTION/ABSTRACT
 The heart requires a constant supply of ATP to meet its high energy demands and maintain its contractile
function. The relationship between cardiac energy deficiency and heart failure has been extensively studied,
leading to various strategies to improve energy deficiency in heart failure. However, despite these efforts,
limitations persist, and the energy deficit in failing hearts remains. A more comprehensive understanding that
moves beyond our current linear model of energy production and consumption is needed to address this
challenge. In this project, the investigators proposed exploring the metabolic resuscitation system, a revival
mechanism profoundly downregulated in heart failure patients. The overarching objective of this program is to
determine the connection between a compromised metabolic resuscitation system and the pathogenesis of
heart failure and revival. Comprehensive experimental approaches and patient-related genetic animal models
are applied to investigate this new system. The eventual results will allow a look from a different angle to
understand the progression of HF. Manipulating the novel factors in this system could be a novel therapeutic
strategy and potential new biomarkers for heart failure treatment and prevention, eventually improving heart
failure patient outcomes. The project expects to achieve three main objectives: defining the functional and
pathological significance of this system in the heart, uncovering the regulation of this resuscitative mechanism,
and exploring its translational potential for preventing and treating heart failure patients.

## Key facts

- **NIH application ID:** 11000149
- **Project number:** 1R01HL176015-01
- **Recipient organization:** TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
- **Principal Investigator:** Jiang Chang
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $748,829
- **Award type:** 1
- **Project period:** 2024-07-01 → 2028-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11000149

## Citation

> US National Institutes of Health, RePORTER application 11000149, Metabolic Resuscitation in Heart Failure. (1R01HL176015-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/11000149. Licensed CC0.

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