Project Summary T cells play a pivotal role in various neurological disorders, and their involvement is a critical aspect of the immune response within the central nervous system. Despite the significance of T cells in neuroinflammation and neurodegenerative processes, the identification of T cell targets in these contexts remain challenging. In recent years, advancements in basic and clinical neuroimmunology have improved our comprehension of T cell pathophysiology in neurological disorders. However, research efforts often exist in isolation, lacking a unified platform for meaningful collaboration between basic immunologists, neuropathologists, T cell engineers, computational biologists and clinicians. To address this gap, “T Cells in the Brain 2025 (TCB2025): Decoding T Cell Targets in Neurodegenerative Diseases” aims to consolidate recent scientific progress and integrative approaches towards T cell-related therapy. This conference will bring together experts in the field to share cutting-edge insights and foster interdisciplinary discussions that can catalyze the development of therapeutic interventions targeting T cells in neurodegenerative diseases. Recognizing the importance of diversity in scientific research, TCB is committed to enhancing inclusivity by actively encouraging the participation of young investigators, women, and underrepresented minority (URM) researchers. By providing a platform for collaborative discourse, TCB aspires to accelerate the development of effective T cell-based therapies for neurodegenerative disorders.