# Non-Invasive Venous Waveform Analysis (NIVA) in patients with Heart Failure (HF)

> **NIH NIH R44** · VOLUMETRIX, LLC · 2024 · $175,700

## Abstract

Project Summary
Volume overload (congestion) occurs in patients with heart failure (HF) and is the leading cause
of hospitalization in the elderly worldwide. Unfortunately, clinical signs and symptoms;
laboratory values; and existing diagnostic tools are unreliable in providing accurate assessment
of volume status. Using a unique physiologic signal, Non-Invasive Venous waveform Analysis
(NIVA), VoluMetrix has developed a proprietary device and algorithm designed for monitoring
volume status in HF patients. Proof of concept data in humans and experimental animal
models, demonstrate that NIVA provides a reliable indication of intravascular volume status
(“pulmonary capillary wedge equivalent”). The work in this Phase IIB proposal will establish
interface and usability studies to complete the process necessary for bridging the gap to
commercialization.

## Key facts

- **NIH application ID:** 11001052
- **Project number:** 3R44HL140669-05S1
- **Recipient organization:** VOLUMETRIX, LLC
- **Principal Investigator:** Kyle Mitchell Hocking
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $175,700
- **Award type:** 3
- **Project period:** 2018-08-21 → 2026-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11001052

## Citation

> US National Institutes of Health, RePORTER application 11001052, Non-Invasive Venous Waveform Analysis (NIVA) in patients with Heart Failure (HF) (3R44HL140669-05S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/11001052. Licensed CC0.

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