PROJECT SUMMARY/ABSTRACT This project is intended to support Dr. Nusayba Bagegni as an early career cancer clinical investigator and clinical trialist with a focus on breast cancer and developmental therapeutics at Washington University School of Medicine, Siteman Cancer Center to support NCI-funded clinical research activities and training. The Applicant's interest is in designing and conducting early-phase breast cancer clinical trials and identifying predictive biomarkers of response and resistance to improve breast cancer outcomes for those with aggressive breast cancer subtypes and advanced breast cancer. The Applicant is committed to establishing an academic career in clinical research, serving both as site and overall PI for a number of NCI-funded therapeutic and interventional clinical trials. The Applicant is vigorously involved in developing and implementing investigator- initiated trials to address unmet need for aggressive breast cancer subtypes requiring novel therapeutic approaches, as well as trials of therapy efficacy monitoring, and inclusion of underrepresented minorities, the latter of which is extremely lacking in breast cancer clinical trials.