SUMMARY The rhesus macaque (Macaca mulatta) is the most commonly used nonhuman primate model in biomedical research. Nonhuman primate models are of growing importance for HIV/AIDS-related research to develop vaccines, therapeutic interventions a potential cure and other approaches. However, it is well-known that the demand by the research community of rhesus macaques, remains greater than their availability. The CPRC have been critical for maintaining the momentum of NIH-supported. Over the last three years (2020-2023), 700 animals (app 230/year) have been available from this program supporting $57,866,376 of NIH-high priority HIV/AIDS-research, mainly R01, P01, U01- funded academic investigators and NIAID-DAIDS-SVEU programs. This NOFO presents an opportune moment to bolster CPRC's SPF program, aiming to add at least 350 new animals in 5 years and 1,000 in 10 years, significantly enhancing the Center's resources for cutting- edge research on NIH-funded HIV/AIDS.