Abstract The robust nonhuman primate (NHP) SIV/AIDS research portfolio at the Emory National Primate Research Center (ENPRC), which reached $23.8 million in FY2023 alone, has placed significant and unsustainable demands on the Emory NPRC rhesus macaque SPF breeding colony. To meet the current and projected future research demand, ENPRC is proposing to demolish an existing small NHP run housing building at the ENPRC Field Station from 1969 that needs to be decommissioned, and replace it with a larger run housing building to facilitate expansion of the SPF breeding colony. The new animal housing proposed will consist of 16 indoor/outdoor run housing areas as well as a cage housing room and clinical support space. This run housing will provide optimal small group breeding to support SIV/AIDS research by facilitating targeted genetic breeding for specific research requests, as well as colony management space needed to optimize breeding. The proposed new animal housing at the Field Station will allow for significant expansion of the SPF rhesus macaque colony over the next five years, thus providing additional animals to support the current and projected SIV/AIDS research program for investigators at Emory NPRC as well as for external collaborators to address the nationwide shortage of NHPs for research.