PROJECT SUMMARY/ABSTRACT Oral and long acting injectable (LAI) pre-exposure prophylaxis (PrEP), an effective evidence-based HIV prevention intervention, is underutilized among Latino gay, bisexual, and other men who have sex with men (LMSM) in the US. Nationally, only 21% of PrEP-eligible Latina/o/x individuals (mostly LMSM) were on PrEP, while representing 30% of all new HIV diagnoses among MSM. In Georgia (GA), while HIV diagnoses have decreased overall, new HIV diagnoses among Latino men (80% MSM) increased by 13% between 2010-2019. Our group identified a scarcity of PrEP clinics able to provide culturally concordant PrEP care to LMSM in Atlanta. In addition, despite LAI PrEP’s superior efficacy compared to oral PrEP, its implementation in Southern states without Medicaid expansion (such as GA) has been difficult. Federally Qualified Health Centers (FQHCs) are the ideal setting to implement culturally tailored strategies to increase oral and LAI PrEP uptake among LMSM, but there is a technical capacity gap to address PrEP-, MSM-, and Latino-specific needs. To address this gap, through direct partnership with two local community-based organizations and health departments, the objective of the proposed implementation science research project is to develop and pilot IntégraTE, an implementation strategy to increase oral and LAI PrEP accessibility and quality of care for LMSM in 3 FQHCs in the Atlanta Metropolitan Area. We will first conduct an explanatory qualitative assessment at 3 FQHCs through focus group discussions (FGD) to identify major barriers and facilitators of providing oral and LAI PrEP services for LMSM. Through these findings and leveraging co-mentors Sheth/Sales prior work, we will develop the IntégraTE strategy, an LMSM-tailored set of oral and LAI PrEP trainings and technical assistance for 3 FQHCs. Lastly, in a pre/post implementation mixed methods study design, we will assess the strategy’s reach, acceptability, feasibility, appropriateness, implementation, timeliness, satisfaction, and cultural competence, through surveys to 50 clinic personnel and 60 LMSM, FGDs among clinic personnel, electronical health record chart abstraction, and direct observations of day-to-day clinic activities. Our community-academia-public health partnership is ideally suited to carry out the proposed study, as we have demonstrated ability to recruit 44 LMSM during the SaludFindr study and 70 LMSM for the CREEMOS study, with both studies reaching 80% retention. In line with the Minority HIV Research Initiative (MARI) objectives and the End the HIV Epidemic Prevent pillar, this research will support the development of the first implementation strategy seeking to improve PrEP accessibility for LMSM in the Atlanta area at the service provision level. Results from this study will serve as preliminary data to prepare a NIH R01 application to conduct a hybrid type-2 effectiveness implementation study to 1) identify factors associated with clinic-level ado...