The Partnership for Native American Cancer Prevention (NACP) is an ongoing 21-year old collaboration between Northern Arizona University (NAU), an institution serving underserved heath disparity populations and underrepresented students (ISUPS), and the University of Arizona Cancer Center (UACC), a National Cancer Institute-Designated Comprehensive Cancer Center. NACP will focus on health equity as Native American teachings speak to a positive path for creating a healthy future. The overarching goals and objectives of the NACP are to reduce the cancer burden within the Arizona Native American population through research and community engagement; expand the number of Native American investigators working in cancer research; and increase the total number of investigators focused on Native American cancer health equity. The NACP Administrative Core is the essential central component of NACP that brings together the inter- institutional leadership to administer, coordinate and manage the U54 goals and aims. The Administrative Core ensures alignment, integration, communication, and transparency occurs between the respective Cores, Shared Resource, and research projects. The Core is responsible for NIH reporting, institutional accountability, including the interaction with the UACC Office of Community Outreach and Engagement (COE), overall financial management, tracking of specific aims progress, process Core and project evaluations, and facilitates the interactions and communications with the three advisory committees: Internal Advisory Committee (IAC), Program Steering Committee (PSC), and the Community Advisory Board (CAB). The Administrative Core will also initiate recruitment of Early-Stage Investigators (ESI) focused on cancer health disparity research that will benefit tribal communities. To ensure the success of NACP’s goals and objectives outlined throughout this application, the Administrative Core is charged with the following aims: Aim 1. Engage a Partnership leadership team that integrates all the research projects, Cores, and Shared Resource activities in support of NACP goals and objectives, with a particular focus on supporting early stage investigators (ESI). Aim 2. Provide administrative management for the entire Partnership including facilitating communication between Cores and research projects, fiscal management of all components, and community dissemination. Aim 3. Coordinate the participation of the three advisory boards within NACP’s planning and evaluation activities and interface with NCI CPACHE providing timely reports and responses to request for information. Aim 4: Collaborate with the UACC Office of Community Outreach and Engagement (COE) to address cancer health equity throughout the state and the World Indigenous Cancer Conference organizers to provide an international NACP impact.