# Developing novel technologies to monitor nociception and opioid administration during surgery and general anesthesia to minimize postoperative opioid requirements

> **NIH NIH R42** · PASCALL SYSTEMS, INCORPORATED · 2024 · $221,325

## Abstract

PROJECT SUMMARY
In light of the opioid crises, minimizing postoperative pain and postoperative opioid requirements to reduce
chronic opioid dependency among surgical patients have become major concerns for surgeons and
anesthesiologists. Effective intraoperative nociception control can mitigate these concerns. Unfortunately,
existing nociceptive monitoring tools use indicators that are inherently susceptible to intraoperative influences.
Monitoring these indicators often lead to suboptimal intraoperative opioid administration, since there is no way
to account for whether these measures are being influenced by nociception or numerous other intraoperative
factors such as blood loss, anesthetic drugs and antihypertensives. Therefore, improved methods to monitor
surgical nociception are clearly needed. In short, currently available nociceptive monitors measure unreliable
indicators and predispose surgical patients to suboptimal opioid dosing administration leading to ineffective
intraoperative control. The consequences for surgical patients can be significant, since increased postoperative
pain and opioid requirements is associated with increased incidence of opioid dependency. This project
proposes to develop a state-of-the-art sensors, algorithms, and prospective observational data to construct an
integrated measure of nociceptive control based on autonomic (EDA) and neurophysiologic markers of arousal
and nociception (EEG-based arousal and opioid signatures).

## Key facts

- **NIH application ID:** 11012570
- **Project number:** 3R42DA053075-03S1
- **Recipient organization:** PASCALL SYSTEMS, INCORPORATED
- **Principal Investigator:** Tuan Le Mau
- **Activity code:** R42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $221,325
- **Award type:** 3
- **Project period:** 2020-09-15 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11012570

## Citation

> US National Institutes of Health, RePORTER application 11012570, Developing novel technologies to monitor nociception and opioid administration during surgery and general anesthesia to minimize postoperative opioid requirements (3R42DA053075-03S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/11012570. Licensed CC0.

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