PROJECT SUMMARY The Veterinary Medical Diagnostic Laboratory (VMDL) at the University of Missouri (MU) is a full- service for all animal species diagnostic laboratory and it is Missouri’s only laboratory accredited by the American Association of Veterinary Laboratory Diagnosticians (AAVLD). The VMDL is a Tier I Laboratory of the Food and Drug Administration (FDA) Veterinary Laboratory Investigation and Response Network (Vet-LIRN). In addition, the VMDL is a Level I Lab of the National Animal Health Laboratory Network (NAHLN). The VMDL provides in-depth laboratory diagnostic support to MU Veterinary Teaching Hospital, non-MU veterinary practitioners, livestock and poultry industry, stakeholders in companion animal health, wildlife conservationists, and state and federal regulatory agencies. The goal of this application is to maintain the VMDL’s strong support to FDA Vet-LIRN mission in investigating potential adverse events affecting the nation’s food or animal feed supply by testing veterinary products, animal feeds or diagnostic samples. The specific aims are to 1). participation in FDA/Vet-LIRN sample analysis, 2). provide analytical data to support potential regulatory use, and 3). participate in additional projects, such as method development and validation as determined by the VPO. The infrastructure funding will enable the VMDL to better support FDA CVM’s capacity and capability to conduct case investigations.