Project Summary This supplement project is to support Justin Gonzalez in a postbaccalaureate research and career development training experience alongside the goals of R01GM146386. Justin will engage with students receiving focused career development training through other scaffolded programming at the University of Minnesota, and gain research skills towards application to graduate programs or other long term career goals in biomedical research. He will also engage with his mentor, Dr. Parker, in weekly research and career development discussions to help him in his exploration of research areas and graduate program opportunities. He will work on a research project to test novel substrates for the TAM family of kinases that were designed using AI-based structural approaches, and characterize the kinetic parameters for substrate-kinase pairs.