Project Summary The Delaware IDeA Network of Biomedical Research Excellence (DE-INBRE) catalyzes multidisciplinary biomedical research initiatives that build Delaware’s biomedical research capacity and workforce. The DE- INBRE network consists of five network partner institutions (NPIs): The University of Delaware, a Carnegie R1- doctoral intensive- very high research activity university which also has three associate-in-arts campuses, leads the DE-INBRE program in partnership with two minority-serving primarily undergraduate institutions (PUIs), Delaware State University (DSU) and Delaware Technical Community College, along with two medical institutions, Christiana Care Health System and Nemours Children’s Health-Delaware. DE-INBRE’s Administrative (ADMIN) core provides logistic/administrative support to all DE-INBRE activities while ensuring compliance with all federal, state and institutional policies, administers a robust Student Research Program that provides mentored scientific research internships to Delaware’s undergraduates, a comprehensive set of Professional Development workshops that foster the success of scientists ranging from undergraduates through faculty, and an Evaluation program that ensures that all DE-INBRE programs are contributing to its mission. The Data Science core supports computational resources, access to biomedical datasets, data science consulting, and the development/dissemination of workshops that train investigators in data science methodology. The Renovation component supports the physical infrastructure needed for DSU to establish at Data Science Laboratory to foster expansion of Data Science research at this HBCU. The DRPP program administers a research grant program that provides seed funding to Delaware’s early stage and new investigators to launch successful biomedical research careers. The Centralized Shared Resources core ensures that Delaware’s scientific community has ready access to a network of 20 core facilities located across Delaware by supporting policies that keep core access open to investigators at all NPIs, vouchers to support investigator core use, training of core facility staff in core management and new technologies. All DE-INBRE components synergize into a robust initiative that will make a major impact on Delaware’s research community.